2026 NFL picks, score predictions for every Week 4 game

In the blink of an eye, the month of September is gone, and the 2026 NFL season is officially in full swing.

After an absolutely amazing slate of games in Week 3, NFL fans will be in for a treat with some big-time matchups in Week 4. This particular week has it all, starting with an underrated divisional matchup on Thursday night between the Steelers and Browns.

As fun as that game is now, it’s far from over. We’ve got the first Patriots-Bills matchup of the season. The undefeated Raiders host the undefeated Chiefs. The Broncos and 49ers have a showdown in San Francisco. The Jaguars will take on the Bengals in what could be an epic shootout.

There’s a lot coming in, so let’s not waste any more time. Here are our official Week 4 picks and score predictions for every game on the schedule.

2026 NFL Picks and Score Predictions for Every Week 4 Game

Pittsburgh Steelers (2-1) @ Cleveland Browns (2-1)

Thursday, October 1, 8:15 PM ET

Heading into Week 3 action, this matchup between the Pittsburgh Steelers and Cleveland Browns is about as interesting a primetime matchup as you could possibly make.

now?

Flipped the script. Not only is this game interesting on paper, but it has some real implications in the AFC North. Yes, it’s still early in the season, but the Cleveland Browns are 2-1 and tied for the best record in the division. In fact, literally every team in the AFC North is 2-1.

Every game is very important, and the Browns are playing great football, so let’s just start there.

We’ve all taken our shots at Deshaun Watson, and rightfully so. Watson has been awful for a long time when we’ve actually seen him on the field. He is one of the biggest distractions out of the league. His contract is an albatross. There’s no way the Browns are going to play good football this season with Watson at the helm.

Until they did.

I personally am of the opinion that playing Watson is a colossal waste of time for the Browns. I had to eat crow on that take. He’s played great football the past two weeks, leading the Browns to impressive wins over the Buccaneers and Panthers.

Speaking of eating crow, the Steelers also fed me this past week. Their win over the Bengals was one of the most impressive of the week, not because they won by a huge margin, but because they really put it together offensively.

Up to this matchup in a short week? I think whatever you decide you’re going to expect, it’s going to be the opposite of that. Expecting a defensive battle? It’s going to be a shootout. Expecting a wacky shootout? It will be a barn-burner.

The Steelers are 2.5-point favorites on the road but I’ll buy that the clock won’t strike midnight on the Browns.

Prediction: Browns win 27-23

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