The Week 4 NFL odds board is the last moment with 16 games as the bye begins in Week 5. But before that, the league makes its first trip to London with the Colts vs. Commanders, which favored Indy by 3.5 points. Also on Sunday, there are only two divisional contests, with the Patriots vs. Bills (-7) and Chiefs vs. Raiders (+4.5). However, Monday has a divisional matchup, which also doubles as an anniversary game. The Saints are 2.5-point favorites over the Falcons, per the NFL’s Week 4 spread, since it was the 20th anniversary of New Orleans’ “Domecoming” in 2006. Claim the latest Polymarket promo code CBSSPORTS to get $25 bonus after $10 in trades:
If looking to pick Week 4 NFL games with heavy favorites, then two teams stand out. The Ravens are 11.5-point favorites over the winless Titans, and the Vikings are favored by 10 points against 0-3 Miami. All updated Week 4 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 4 NFL picks today.
The model, which simulates every NFL game 10,000 times, has raised more than $7,000 for $100 players on betting sites on top NFL picks since its inception. The model enters Week 4 of the 2026 NFL season on a 54-43 run among the top-rated picks dating back to 2024. Anyone following its picks on NFL betting sites can see strong returns.
Now, it turns its attention to the latest Week 4 NFL odds and NFL betting lines and locked in betting picks for every NFL matchup. Go here to see each selection.
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Top Week 4 NFL predictions
We can tell you one of the NFL’s strongest Week 4 picks for best betting apps is that the Giants (+2.5, 44.5) cover against the Cardinals in a Sunday 1 pm ET kickoff. Arizona’s Week 1 win over the Chargers looks less impressive every week, considering both opponents and the Cards have allowed 31-plus points in the losing streak since. Arizona is just 5-9 ATS after a loss since the start of last year, while New York has won games by margins. The Giants lead the NFL in time of possession on offense, as well as starting field position on defense. The model has New York covering more than 50% of the time and also wants Over to cover 56% of the time. See which other teams will be selected here.
Another of its Week 4 NFL predictions: the Seahawks (-7, 42.5) cover against the Chargers. LA forced five turnovers against the Bills on Sunday but still lost as the Chargers dropped six straight starts last year. They’ve scored 17 or less in all six and now have to face a miserable Seahawks squad that just ended its 12-game win streak. That was after a cross-country flight to Washington, but the Seahawks return to Seattle on Sunday, where it will be a calendar year since their last loss. Justin Herbert has 10 touchdowns against 11 turnovers in his last 10 games overall as Seattle is projected to cover the spread in nearly 60% of simulations, with the Over hitting more than 60% of the time. See which other teams will be selected here.
How to make Week 4 NFL picks
The model also calls out who will win and cover every other game on the NFL’s Week 4 schedule and just revealed five teams projected to win by double digits, potentially giving you a big payday on alternate lines. You can only get every pick for every game on SportsLine.
So which Week 4 NFL picks can you make with confidence, and which five picks should you lock in right now? Check out the latest NFL odds below, then visit SportsLine to see which teams will win and cover the spread, all from a proven computer model that has returned more than $7,000, and find out.
Week 4 NFL betting odds, lines, spreads, scores
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