The final game of Week 6 is a Monday Night Football matchup featuring the Washington Commanders (1-3-1) on the road against the San Francisco 49ers (5-0).
The 49ers lead the all-time series between these teams, 20-11-1, and have won three of their last four meetings. They last faced off in 2023, when the 49ers had an early morning on the East Coast against the Commanders, winning 27-10.
Here’s everything you need to know about tonight’s game.
Washington Commanders vs. San Francisco 49ers
Date: Monday, October 18, 2026
Location: Levi’s Superdome | Santa Clara, CA
Announcers: Joe Buck, Troy Aiman, Lisa Salters (field reporter) and Laura Rutledge (field reporter)
Washington Commanders: +7.5 (+330)
San Francisco 49ers: -7.5 (-420)
Open thread: Discuss Monday night’s game in the comments below.