A few unusual matchups on the NFL’s Week 7 schedule should give a little extra appeal to making Week 7 NFL bets. The Giants vs. Texans (-10) New York visits Houston for the first time in eight years, while Rams vs. Raiders (+4) have LA travel to Vegas for the first time since the latter moved from Oakland. Elsewhere, the Chiefs head to Seattle for the first time since 2018, and the latest Week 7 NFL odds have Seattle as 2.5-point favorites in this potential Super Bowl preview. Visit our Kalshi promo code review and get $55 bonus after $25+ in trades with Kalshi promo code CBSSPORTS55:
Additionally, the first NFL Paris Game favored Pittsburgh by 3.5 points over New Orleans in France. There are also some divisional contests with slim Week 7 NFL spreads including Ravens vs. Bengals (+2.5), Packers vs. Lions (-3) and Panthers vs. Buccaneers (+3.5). All updated Week 7 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 7 NFL picks today.
The model, which simulates every NFL game 10,000 times, has raised more than $5,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model enters Week 7 of the 2026 NFL season with a 58-48 run over the top-rated picks dating back to 2024. Anyone following its picks on NFL betting sites can see strong returns.
Now, it turns its attention to the latest Week 7 NFL odds and NFL betting lines and locked in bets for every NFL matchup. Go here to see each selection.
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Top Week 7 NFL predictions
We can tell you one of the model’s strongest Week 7 NFL picks for best betting apps is the coverage of the Jets (-4.5, 39.5) at home against the Dolphins in a 1 pm ET kickoff. New York’s four wins are tied for a league-high of five, while Miami’s one ATS win is tied for second-lowest in the NFL. The Jets have a defense that ranks in the top seven in points allowed, passing defense and redzone scoring, and the offense got a big boost from the return of first round wideout Omar Cooper, who had a 6-103-1 stat line entering Sunday. Miami is close, but the Dolphins are also 0-3 ATS in their last three games with the rest advantage, as the Jets are projected to cover more than 60% of the time with an A-rated pick. See which other teams will be selected here.
Another of its Week 7 NFL predictions: the Broncos (-4.5, 43.5) cover the Cardinals in more than 50% of simulations. Denver’s outright and spread results mirror each other with a 4-2 record, including sweeping both games as the favorite. The Cardinals are 0-2 against the line at home this season and an eye-popping 1-9 ATS at home since the start of 2025. Arizona is one of two teams to rank in the bottom 10 in both scoring offense and scoring defense, along with Miami, while Denver boasts top-5 rankings in both takeaways and turnover differential. In addition to Denver covering, the Under hits over 50% of the time. See which other teams will be selected here.
How to make Week 7 NFL picks
The model also calls out who will win and cover every other game on the Week 7 NFL schedule and reveals just six expected total points of at least a touchdown from listed O/U, potentially giving you a big payday in alternative totals. You can only get every pick for every game on SportsLine.
So which Week 7 NFL picks can you make with confidence, and which six O/U picks should you lock in right now? Check out the latest NFL odds below, then visit SportsLine to see which teams will win and cover the spread, all from a proven computer model that has returned more than $5,000, and find out.
Week 7 NFL betting odds, lines, spreads, scores
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