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San Francisco 49ers edge rusher Nick Bosa.
The undefeated San Francisco 49ers will be without two of the NFL’s best players at their respective positions against the Seattle Seahawks in Week 5, with NFL All-Pro fullback Kyle Juszczyk and NFL All-Pro edge rusher Nick Bosa both on the inactive list.
While Bosa will be out again, the 49ers got a boost in the season debut of edge rusher and 2025 1st-round pick Mykel Williams, who hasn’t played since tearing his ACL in Week 9 of his rookie year.
“49ers inactive vs. Seattle: DE Nick Bosa (leg), FB Kyle Juszczyk (knee), DT James Thompson Jr. (ankle), S Marques Sigle (ankle), QB Kurtis Rourke (3rd QB), OT Enrique Cruz Jr., LB Tatum Bethune,” ESPN’s Nick Wagoner wrote on his official X account on Sunday.
Nick Bosa Teases Return for Monday Night Football
Bosa appears set to return in Week 6 for a Monday Night Football game against the Washington Commanders.
“N.G Nick Bosa (calf) told me he’s ‘pretty darn likely’ to play in the 49ers’ Week 6 game against the Commanders at MNF,” NBC Sports NFL reporter Matt Maiocco wrote on his official X account on Oct. 9.
Bosa hasn’t played since a Week 2 win over the Miami Dolphins and missed 14 games in 2025 after tearing his ACL in Week 3.
The loss of Kyle Juszczyk hurts the 49ers Offense
Juszczyk was hurt by a low hit in a win over the Denver Broncos in Week 4 — and his injury could spell trouble for the offense.
“I can imagine … losing Kyle Juszczyk for the 49ers was a game-losing injury,” ESPN’s Ben Solak wrote on Oct. 6. “Juszczyk, who left Sunday’s game against the Broncos in the fourth quarter, has a bone bruise and is out for three to four weeks. Normally, a fullback injury might go unnoticed — heck, any injury for a player with four touches in four games. But move on Juszczyk on 61 snaps, second only to Buccaneers WR Emeka Egbuka. He’s more important to the 49ers’ running game — both as a point-of-attack blocker and his versatility where he lines up — than any other skill position player in the league. The 49ers should still throw the ball well, but carrying a one-dimensional offense into a game against the Seahawks feels dangerous.
Tony Adam covers the NFL for Heavy.com, with a focus on the Denver Broncos, Baltimore Ravens, Buffalo Bills, Tampa Bay Buccaneers, San Francisco 49ers, and the entire NFC East Division. A veteran sports writer and editor since 2004, his work has been featured in Stadium Talk, Yardbarker, NW Florida Daily News and Pensacola News Journal. More about Tony Adame