The final game of Week 5 is a Monday Night Football matchup featuring the Buffalo Bills (3-1) on the road against the Los Angeles Rams (2-2).
The Bills lead the all-time series between these teams, 9-6, and have won three of their last four meetings. However, the last time they met, in 2024, the Rams won at home in Los Angeles, 44-42.
“BUFFALO BILLS at LOS ANGELES RAMS: AFC team to NFC team. Root for the Bills.“
Here’s everything you need to know about tonight’s game.
Buffalo Bills vs. Los Angeles Rams
Date: Monday, October 12, 2026
Location: SoFi Stadium | Inglewood, CA
Announcers: Joe Buck, Troy Aikman, Lisa Salters (field reporter), Laura Rutledge (field reporter)
Buffalo Bills: +3.5 (-152)
Los Angeles Rams: -3.5 (-180)
Open thread: Discuss Monday night’s game in the comments below.